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Bioorthogonal chemistry(生物正交化学)

Bioorthogonal chemistry(生物正交化学) DBCO , BCN , PEG modified propyne and azide, S-tetrazine series, TCO and cyclopropene and other excellent bio-orthogonal reaction reagents.
Dibenzocyclooctyne (DBCO)
Dibenzocyclooctyne (DBCO)
DBCO (Dibenzocyclooctyne) is used in the azido-acetylene cycloaddition (SPAAC) reaction without the catalysis of copper ions. The second-order kinetic constant of this reaction can reach 1.The DBCO family of products includes DBCO-ACID, DBCO-amine, DBCO-PEG-COOH, DBCO-PEG-amine which can be used for further linkage, as well as DBCO-labeled Biotin, fluorescent dyes and biochemical small molecules.
1,2,4,5-tetrazine(1,2,4,5-四嗪)
1,2,4,5-tetrazine(1,2,4,5-四嗪)
1,2,4,5 - four oxazine with large tensile ring olefins, such as the small size of the ring propylene and trans cyclooctene (TCO) for biological orthogonal with the fastest reaction rate without catalyst, has been successfully applied to the antibody tag and a variety of applications such as protein modification.
Cyclopropene(环丙烯)
Cyclopropene(环丙烯)
Cyclopropene, as an amphiphilic diene, has a fast reaction rate with s-tetrazine. Because of the smaller size of cyclopropene compared with TCO, it is very suitable for labeling biochemical small molecules without affecting their original functions.
 
Bio-orthogonal Shear reaction(生物正交剪切反应)
Bio-orthogonal Shear reaction(生物正交剪切反应)
(2E)-TCO, N-​(2E)-TCO-L-lysine, as amphiphilic Diene, can react with s-tetrazine by bio-orthogonal Shear.
 
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